Effects of various drugs and vagotomy on indomethacin-induced gastric ulcers in the rat.
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چکیده
منابع مشابه
Effects of Aloe vera, Camellia sinensis, Hibiscus sabdariffa and Sophora alopecuroides in Rat Model of Indomethacin-Induced Gastric Ulcer
Background: Evidences show that Aloe vera (A. vera), Camellia sinensis, Hibiscus sabdariffa and Sophora alopecuroides may prevent gastric ulcer induced by non-steroidal anti-inflammatory drugs (NSAIDs). Objective: To examine the protective potential of these plants against indomethacin-induced gastric ulcer in the rat. Methods: Saline, A. vera leaf gel powder and 70% alcoholic extracts of...
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Background: Saffron is the dried stigmata of the flowers of saffron (Crocus sativus L., Iridaceae). Saffron is well known for the treatment of gastric disorders in traditional medicine. Objectives: In the search for new potential antiulcer agents, the effects of the ethanol extract of saffron and its active constituents crocin and safranal as compared with omeprazole against gastric ulcer i...
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Background: Data suggest that V. arctostaphylos, B. thunbergii var. atropurpurea, E. angustifolia and L. acanthodes may prevent gastric ulcers induced by Non-steroidal anti-inflammatory drugs (NSAIDs). Objective: To explore the ulcer-protective potential of these plants in indomethacin-induced gastric ulcers in rats. Methods: Saline, hydro-alcoholic extract of each plant (100, 400, 800 mg/...
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Background and Objective: Although Ferula spices have been used in traditional medicine, their therapeutic effects on gastric ulcers have not yet been proven in modern medicine. In this study we examined the healing effects of the root powder of Ferula Ovina against indomethacin-induced gastric ulcers in male rats. Materials and Method: In this experimental study 56 male rats (280-320gr) wer...
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Introduction: Indomethacin increases generation of mitochondrial reactive oxygen species (ROS) which have a crucial role in the indomethacin-induced gastric ulcer. Coenzyme Q10 has an antioxidant activity on mitochondria and cell membranes and protects lipids from oxidation and is essential for stabilizing biological membranes. Superoxide dismutase (SOD) acts as one of the defense mechanisms ag...
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عنوان ژورنال:
- Japanese journal of pharmacology
دوره 29 4 شماره
صفحات -
تاریخ انتشار 1979